22 March, 2017
Victoria Hall, Geneva, Rue Général-Dufour 14, 1204 Geneva

Nelson Freire and L’Orchestre de la Suisse Romande directed by Jonathan Nott

To celebrate the 100th anniversary of the birth of Dinu Lipatti, the Dr Henri Dubois-Ferrière Dinu Lipatti Foundation hopes that you will honour it with your presence at the Gala Concert that will take place at the Victoria Hall on Wednesday 22nd March at 8 pm.

Works
Robert Schumann : Concerto for piano and orchestra in A minor Op. 54
Johannes Brahms : Symphony No 4 in E minor Op. 98
Directed by: Jonathan Nott
Directed by: Nelson Freire

The concert will be followed by a cocktail reception offered by the Mandarin Oriental Geneva at the Restaurant du Parc des Bastions.

The purpose of the evening is to raise funds destined to help advance the fight against leukaemia and other blood cancers.

Cocktail dress

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The medical project

To make the incompatible compatible, to offer life

Stem cell transplantation (or bone marrow allograft) is a complex procedure replacing the diseased bone marrow of a leukemia patient with that of a healthy donor. Currently, this sophisticated technique helps to cure certain patients suffering from leukemia. But not everyone is that lucky. Why is that? Well, it is mainly because the appropriate donor is missing at the right time.

Until now, the goal was to find a 100% compatible donor in order to avoid severe reactions between donor and recipient. Initial researches to find this donor would be carried out within the patient’s brothers and sisters, but the rules of genetics mean that there is only a 25% chance of having an ideal donor (or 100% compatible donor) among siblings. It was therefore necessary to discover another source of stem cells for the majority of patients, using voluntary donors from all over the world. The aim was to identify a kind of biological look-alike in this donor bank, allowing a transplant with maximum safety and efficiency. Unfortunately, we do not all have a look-alike, and leukemia is often faster than this long and tedious process of identification.

What’s the way out of this impasse? Putting an end to certainties, thanks to a revolution in progress! For decades, transplantation clinicians have sought to obtain 100% compatible grafts. Thanks to recent scientific advances, an allogeneic graft is now worth considering with a graft that is only 50% compatible! It’s like putting together a 1000 piece puzzle, using 500 correct pieces and 500 false pieces! But all this is not simple and the main goal of the HUG Hematology team is to succeed, for each single patient, in shaping these pieces into a harmonious puzzle. These advances will broaden the scope of potential donors within families. Indeed, remember that a patient has 50% of his genetic inheritance in common with each biological parent or child. Beyond being scientific and clinical, this progress is therefore also symbolic since it will finally allow the gift of intergenerational life!

Professor Pierre-Yves Dietrich
President of the Scientific Council of the Foundation


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